Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant
نویسندگان
چکیده
منابع مشابه
Primary Graft Dysfunction After Lung Transplantation.
Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of infl...
متن کاملLong Term Impact of Primary Graft Dysfunction after Lung Transplantation
According to the International Society for Heart and Lung Transplantation (ISHLT) Registry, graft failure accounted for 24.7% of deaths within 30 days of transplantation among adult lung recipients between 1992 and 2012 [1]. Although important details distinguishing different causes of early graft failure may be missing from the Registry data, it is likely that primary graft dysfunction (PGD) i...
متن کاملSoluble p-selectin and the risk of primary graft dysfunction after lung transplantation.
BACKGROUND Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation. METHODS In a prospective, multicenter cohort study of 376 patients who had undergone lun...
متن کاملEchocardiographic Detection of Heart Transplant Graft Dysfunction
It would have seemed that the problem is relatively simple: graft rejection or coronary artery disease after cardiac transplantation induces edema, inflammation, myocyte damage, necrosis, ischemia, and sometimes fibrosis, resulting in ventricular systolic and diastolic dysfunction. These should be detectable by echocardiography; yet, the quest for a sufficiently sensitive, specific, and conclus...
متن کاملEchocardiographic Detection of Heart Transplant Graft Dysfunction
It would have seemed that the problem is relatively simple: graft rejection or coronary artery disease after cardiac transplantation induces edema, inflammation, myocyte damage, necrosis, ischemia, and sometimes fibrosis, resulting in ventricular systolic and diastolic dysfunction. These should be detectable by echocardiography; yet, the quest for a sufficiently sensitive, specific, and conclus...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2016
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201508-1522oc